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Article

Hyperacidification of trans-Golgi network and endo/lysosomes in melanocytes by glucosylceramide-dependent V-ATPase activity.

Traffic (Copenhagen, Denmark) - 1 Nov 2011

van der Poel Seléne, Wolthoorn Jasja, van den Heuvel Dave, Egmond Maarten, Groux-Degroote Sophie, Neumann Sylvia, Gerritsen Hans, van Meer Gerrit, Sprong Hein

Abstract excerpt

Sphingolipids are considered to play a key role in protein sorting and membrane trafficking. In melanocytic cells, sorting of lysosomal and melanosomal proteins requires the sphingolipid glucosylceramide (GlcCer). This sorting information is located in the lumenal domain of melanosomal proteins. We found that two processes dependent on lumenal pH, protein sialylation and lysosomal acid lipase (LAL) activity were...

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Identifiers

PMID: 21810155
DOI: 10.1111/j.1600-0854.2011.01263.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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