Article
Changes in the cytoskeletal and nuclear matrix proteins in rat hepatocyte neoplastic nodules in their relation to the process of transformation.
Experimental cell research - 15 Jun 1996
Barboro P, Alberti I, Sanna P, Parodi S, Balbi C, Allera C, Patrone E
Abstract excerpt
In a previous paper (Barboro et al., 1993, Biophys. J. 65, 1690-1699) we have shown that cancer development in the resistant hepatocyte model of Solt and Farber is characterized by the progressive unfolding of the higher-order structure of chromatin. A possible functional role of decondensation phenomena in cell transformation cannot be ruled out. Genetic activation involves the relaxation of the superstructure...
Topics
- Animals
- Antigens, Nuclear
- Biomarkers
- Cations, Divalent
- Chromosomes
- Cytoskeleton
- Electrophoresis, Gel, Two-Dimensional
- Endopeptidases
- Histones
- Humans
- Immunoblotting
- Intermediate Filaments
- Isomerism
- Keratins