Article
Acetaminophen metabolism in patients with different cytochrome P-4502E1 genotypes.
Alcoholism, clinical and experimental research - 1 Feb 1996
Ueshima Y, Tsutsumi M, Takase S, Matsuda Y, Kawahara H
Abstract excerpt
Cytochrome P-450 (CYP) 2E1 is the major ethanol-oxidizing enzyme of the nonalcohol dehydrogenase metabolic pathway in the liver. Recently, the presence of genetic polymorphisms of this enzyme was confirmed. In this study, to clarify the influence of CYP2E1 genotype on alcohol metabolism, we analy...
Topics
- Acetaminophen
- Cytochrome P-450 CYP2E1
- Cytochrome P-450 Enzyme System
- Ethanol
- Genotype
- Half-Life
- Humans
- Liver
- Liver Cirrhosis, Alcoholic
- Liver Diseases, Alcoholic
- Liver Function Tests
- Metabolic Clearance Rate
- Oxidoreductases, N-Demethylating
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Reference Values
- Temperance