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Article

Multiple metabolic signals influence GAL gene activation by modulating the interaction of Gal80p with the transcriptional activator Gal4p.

Molecular microbiology - 1 Oct 2010

Li Yan, Chen Guanjun, Liu Weifeng

Abstract excerpt

Transcriptional status of the genes needed for galactose utilization in Saccharomyces cerevisiae is controlled by the interplay between the prototypical transcriptional activator Gal4p and the inhibitor protein Gal80p. Relief of the inhibition from Gal4p requires the interaction between Gal80p and the galactokinase paralog, Gal3p. Here, we present evidence that decrease in the intracellular levels of ATP or...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20979343
DOI: 10.1111/j.1365-2958.2010.07343.x

Genes

GAL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Multiple metabolic signals influence GAL gene activation by modulating the interaction of Gal80p with the transcriptional activator Gal4p.PMID 20979343Read ↗

Galactose-dependent reversible interaction of Gal3p with Gal80p in the induction pathway of Gal4p-activated genes of Saccharomyces cerevisiae.Semantic proximity Read ↗

Transcriptional control of the GAL/MEL regulon of yeast Saccharomyces cerevisiae: mechanism of galactose-mediated signal transduction.Semantic proximity Read ↗

The Gal3p transducer of the GAL regulon interacts with the Gal80p repressor in its ligand-induced closed conformation.Semantic proximity Read ↗

Activation of Gal4p by galactose-dependent interaction of galactokinase and Gal80p.Semantic proximity Read ↗

Identification of ATP-NADH kinase isozymes and their contribution to supply of NADP(H) in Saccharomyces cerevisiae.Semantic proximity Read ↗

Intracellular NADPH levels affect the oligomeric state of the glucose 6-phosphate dehydrogenase.Semantic proximity Read ↗

Replacement of a conserved tyrosine by tryptophan in Gal3p of Saccharomyces cerevisiae reduces constitutive activity: implications for signal transduction in the GAL regulon.Semantic proximity Read ↗

GAL4 mutations that separate the transcriptional activation and GAL80-interactive functions of the yeast GAL4 protein.Semantic proximity Read ↗

Partial rescue of pos5 mutants by YEF1 and UTR1 genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

Self-association of the Gal4 inhibitor protein Gal80 is impaired by Gal3: evidence for a new mechanism in the GAL gene switch.Semantic proximity Read ↗

Intracellular galactose-1-phosphate accumulation leads to environmental stress response in yeast model.Semantic proximity Read ↗

Novel Gal3 proteins showing altered Gal80p binding cause constitutive transcription of Gal4p-activated genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

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