Article
Roles of the three Mycobacterium smegmatis katG genes for peroxide detoxification and isoniazid susceptibility.
Microbiology and immunology - 1 Mar 2018
Iwao Yasuhisa, Nakata Noboru
Abstract excerpt
Three different katG sequences (katGI, katGII and katGIII) were identified in the Mycobacterium smegmatis genome. The contributions of the three katG genes to survival of the bacterium were examined by constructing disruptants of these three genes. The katGIII sequence did not produce a functional catalase-peroxidase. Analyses of peroxidase activity and mRNA expression revealed that in wild type M. smegmatis,...
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