Adenosine kinase of Trypanosoma brucei and its role in susceptibility to adenosine antimetabolites.

Abstract excerpt

Trypanosoma brucei cannot synthesize purines de novo and relies on purine salvage from its hosts to build nucleic acids. With adenosine being a preferred purine source of bloodstream-form trypanosomes, adenosine kinase (AK; EC 2.7.1.20) is likely to be a key player in purine salvage. Adenosine kinase is also of high pharmacological interest, since for many adenosine antimetabolites, phosphorylation is a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Adenosine
• Share to Blotting, Northern
• Share to Deoxyadenosines