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Article

Trypanosomes lacking uracil-DNA glycosylase are hypersensitive to antifolates and present a mutator phenotype.

The international journal of biochemistry & cell biology - 1 Sept 2012

Castillo-Acosta Víctor M, Aguilar-Pereyra Fernando, Vidal Antonio E, Navarro Miguel, Ruiz-Pérez Luis M, González-Pacanowska Dolores

Abstract excerpt

Cells contain low amounts of uracil in DNA which can be the result of dUTP misincorporation during replication or cytosine deamination. Elimination of uracil in the base excision repair pathway yields an abasic site, which is potentially mutagenic unless repaired. The Trypanosoma brucei genome pr...

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PMID: 22728162
DOI: 10.1016/j.biocel.2012.06.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22728162-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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