The mutation rate and cancer.

doi:10.1093/genetics/148.4.1483

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Article

The mutation rate and cancer.

Genetics - 1 Apr 1998

Jackson A L, Loeb L A

Abstract excerpt

The stability of the human genome requires that mutations in the germ line be exceptionally rare events. While most mutations are neutral or have deleterious effects, a limited number of mutations are required for adaptation to environmental changes. Drake has provided evidence that DNA-based mic...

Topics

Animals
Humans
Microsatellite Repeats
Mutation
Neoplasms
Phenotype
Selection, Genetic

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