Concerted action of perforin and granzymes is critical for the elimination of <i>Trypanosoma cruzi</i> from mouse tissues, but prevention of early host death is in addition dependent onthe FasL/Fas pathway

Abstract excerpt

CTL and NK cells are critical for resistance to acute Trypanosoma cruzi infection, but are also implicated in the pathology induced by this intracellular protozoan parasite. Here we explore to what extent the two main cytolytic pathways of CTL and NK cells, i.e. the granule exocytosis and the Fas ligand (FasL)/Fas pathways, are responsible for the elimination of parasites from mouse tissues and control of organ...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biochemical and Molecular Research
• Share to Research on Leishmaniasis Studies
• Share to Trypanosoma species research and implications