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Article

The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particles

1 May 1995

Abstract excerpt

The vpr gene of human immunodeficiency virus type 1 (HIV-1) encodes a virion-associated regulatory protein. Mutagenesis has shown that the virion association of Vpr requires sequences near the C terminus of the HIV-1 Gag polyprotein Pr55gag. To investigate whether Vpr incorporation is mediated by a specific domain of Pr55gag, we examined the ability of chimeric HIV-1/Moloney murine leukemia virus (MLV) Gag...

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Identifiers

PMID: 7707498
DOI: 10.1128/jvi.69.5.2759-2764.1995

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The p6gag domain of human immunodeficiency virus type 1 is sufficient for the incorporation of Vpr into heterologous viral particlesPMID 7707498Read ↗

Incorporation of Vpr into human immunodeficiency virus type 1 requires a direct interaction with the p6 domain of the p55 gag precursor.Semantic proximity Read ↗

A conserved LXXLF sequence is the major determinant in p6gag required for the incorporation of human immunodeficiency virus type 1 VprSemantic proximity Read ↗

A leucine triplet repeat sequence (LXX)4 in p6gag is important for Vpr incorporation into human immunodeficiency virus type 1 particlesSemantic proximity Read ↗

Identification of residues in the N-terminal acidic domain of HIV-1 Vpr essential for virion incorporation.Semantic proximity Read ↗

Nuclear import, virion incorporation, and cell cycle arrest/differentiation are mediated by distinct functional domains of human immunodeficiency virus type 1 VprSemantic proximity Read ↗

Efficient Particle Production by Minimal Gag Constructs Which Retain the Carboxy-Terminal Domain of Human Immunodeficiency Virus Type 1 Capsid-p2 and a Late Assembly DomainSemantic proximity Read ↗

Mutagenic analysis of human immunodeficiency virus type 1 Vpr: role of a predicted N-terminal alpha-helical structure in Vpr nuclear localization and virion incorporationSemantic proximity Read ↗

p6Gag is required for particle production from full-length human immunodeficiency virus type 1 molecular clones expressing proteaseSemantic proximity Read ↗

Human immunodeficiency virus type 1 Vpr: functions and molecular interactionsSemantic proximity Read ↗

Role of the conserved dipeptide Gly75 and Cys76 on HIV-1 Vpr function.Semantic proximity Read ↗

Inhibition of human and simian immunodeficiency virus protease function by targeting Vpx-protease-mutant fusion protein into viral particles.Semantic proximity Read ↗

The nonmyristylated Pr160gag-pol polyprotein of human immunodeficiency virus type 1 interacts with Pr55gag and is incorporated into viruslike particlesSemantic proximity Read ↗

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