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Article

Structural studies of human autoantibodies. Crystal structure of a thyroid peroxidase autoantibody Fab.

The Journal of biological chemistry - 24 May 1996

Chacko S, Padlan E A, Portolano S, McLachlan S M, Rapoport B

Abstract excerpt

The three-dimensional structure of the Fab of TR1.9, a high-affinity IgG1, kappa human autoantibody to thyroid peroxidase, was determined crystallographically to a resolution of 2.0 A. The combining site was found to be relatively flat, like other antibodies to large proteins. Sequence difference...

Topics

Amino Acid Sequence
Autoantibodies
Crystallography, X-Ray
Humans
Immunoglobulin Fab Fragments
Iodide Peroxidase
Molecular Sequence Data
Mutation
Protein Conformation
Sequence Homology, Amino Acid

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Identifiers

PMID: 8647813
DOI: 10.1074/jbc.271.21.12191

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8647813-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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