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Modelling of Thyroid Peroxidase Reveals Insights into Its Enzyme Function and Autoantigenicity

1 Dec 2015

Abstract excerpt

Thyroid peroxidase (TPO) catalyses the biosynthesis of thyroid hormones and is a major autoantigen in Hashimoto's disease--the most common organ-specific autoimmune disease. Epitope mapping studies have shown that the autoimmune response to TPO is directed mainly at two surface regions on the molecule: immunodominant regions A and B (IDR-A, and IDR-B). TPO has been a major target for structural studies for over...

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PMID: 26623656
DOI: 10.1371/journal.pone.0142615

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