Article
Cloning and molecular characterization of a human recombinant IgG Fab binding to the Tat protein of human immunodeficiency virus type 1 (HIV-1) derived from the repertoire of a seronegative patient.
Molecular immunology - 1 Mar 2006
Mancini Nicasio, Perotti Mario, Carletti Silvia, Canducci Filippo, Sampaolo Michela, Clementi Massimo, Burioni Roberto
Abstract excerpt
A study aiming at cloning and characterizing natural antibodies to human immunodeficiency virus type 1 (HIV-1) targets is described. In particular, we report the molecular cloning of a Fab molecule binding the HIV-1/Tat protein from a seronegative patient. The Fab was characterized for its binding specificity and investigated in regards to its molecular structure. Furthermore, to evaluate the role played by the...
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