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Article

Hydrogen bonding and equilibrium isotope enrichment in histidine-containing proteins.

Nature structural biology - 1 Jun 1996

Bowers P M, Klevit R E

Abstract excerpt

We have measured deuterium/hydrogen fractionation in three histidine-containing proteins, ecHPr, ecHPr mutant S31A, and bsHPr, and in random coil peptides using NMR and mass spectrometry. The amide protons of unstructured peptides exhibit equilibrium enrichment for deuterium, in agreement with previous studies. Enrichment for both protium and deuterium was observed in both HPrs, with fractionation factors ranging...

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PMID: 8646538
DOI: 10.1038/nsb0696-522

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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