Article
Predominant deposition of amyloid-beta 42(43) in plaques in cases of Alzheimer's disease and hereditary cerebral hemorrhage associated with mutations in the amyloid precursor protein gene.
The American journal of pathology - 1 Apr 1996
Mann D M, Iwatsubo T, Ihara Y, Cairns N J, Lantos P L, Bogdanovic N, Lannfelt L, Winblad B, Maat-Schieman M L, Rossor M N
Abstract excerpt
Amyloid (A beta) deposition was investigated in cases of Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis, Dutch type, due to mutations in the amyloid precursor protein (APP) gene using the end-specific monoclonal antibodies BA27 and BC05 that recognize A beta 40 or A beta 42(43), respectively. In cases of APP717 mutation the predominant A beta species within plaques terminate at A beta...
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