Article
Visualization of A beta 42(43) and A beta 40 in senile plaques with end-specific A beta monoclonals: evidence that an initially deposited species is A beta 42(43).
Neuron - 1 Jul 1994
Iwatsubo T, Odaka A, Suzuki N, Mizusawa H, Nukina N, Ihara Y
Abstract excerpt
To learn about the carboxy-terminal extent of amyloid beta-protein (A beta) composition of senile plaques (SPs) in the brain affected with Alzheimer's disease (AD), we employed two end-specific monoclonal antibodies as immunocytochemical probes: one is specific for A beta 40, the carboxyl terminu...
Topics
- Adult
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Peptides
- Antibodies, Monoclonal
- Brain
- Cerebral Cortex
- Female
- Humans
- Immunoenzyme Techniques
- Male
- Middle Aged
- Mutation
- Peptide Fragments