Article
HLA-DRB1*13:01 allele in the genetic susceptibility to colorectal carcinoma.
International journal of cancer - 15 May 2015
Aureli Anna, Canossi Angelica, Del Beato Tiziana, Franceschilli Luana, Buonomo Oreste, Papola Franco, De Sanctis Flavio, Lanzilli Giulia, Sileri Pierpaolo, Coppola Andrea, Caratelli Sara, Arriga Roberto, Orlandi Augusto, Lauro Davide, Rossi Piero, Sconocchia Giuseppe
Abstract excerpt
Increasing evidence suggests that HLA-DRB1 alleles reduce or increase the risk of developing ulcerative colitis-associated colorectal carcinoma (CRC) tumors. However, the role of HLA-DRB1 locus on the susceptibility to develop CRC tumor, in the absence of a history of inflammatory bowel diseases (IBDs), is unclear. The aim of our study was to determine whether HLA-DRB1 alleles are associated with IBD-independent...
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