Article
Responses of the phototransduction cascade to dim light.
Proceedings of the National Academy of Sciences of the United States of America - 14 May 1996
Langlois G, Chen C K, Palczewski K, Hurley J B, Vuong T M
Abstract excerpt
The biochemistry of visual excitation is kinetically explored by measuring the activity of the cGMP phosphodiesterase (PDE) at light levels that activate only a few tens of rhodopsin molecules per rod. At 23 degrees C and in the presence of ATP, the pulse of PDE activity lasts 4 s (full width at half maximum). Complementing the rod outer segments (ROS) with rhodopsin kinase (RK) and arrestin or its splice variant...
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