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Article

Reconstitution of human Fc gamma RIII cell type specificity in transgenic mice.

1 Mar 1996

Abstract excerpt

The human low affinity receptors for the Fc domain of immunoglobulin G, Fc gamma RIII, are encoded by two genes (IIIA and IIIB) which share >95% sequence identity in both coding and flanking sequences. Despite this extraordinary sequence conservation, IIIA is expressed in natural killer (NK) cells and macrophages and is absent in neutrophils, whereas IIIB is expressed only in neutrophils. To determine the...

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PMID: 8642269
DOI: 10.1084/jem.183.3.1259

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