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Article

Analysis of the superantigenic activity of mutant and allelic forms of streptococcal pyrogenic exotoxin A.

Infection and immunity - 1 Mar 1996

Kline J B, Collins C M

Abstract excerpt

Infections with Streptococcus pyogenes (group A streptococcus) can result in the recently described streptococcal toxic shock syndrome (STSS), which is characterized by rashes, hypotension, multiorgan failure, and a high mortality rate. S. pyogenes isolates associated with STSS usually produce streptococcal pyrogenic exotoxin A (SpeA), a bacterial superantigen capable of stimulating host immune cells. Most of the...

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Identifiers

PMID: 8641793
DOI: 10.1128/iai.64.3.861-869.1996
PMCID: PMC173849

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