Article
Toxoids of streptococcal pyrogenic exotoxin A are protective in rabbit models of streptococcal toxic shock syndrome.
Infection and immunity - 1 Sept 2000
Roggiani M, Stoehr J A, Olmsted S B, Matsuka Y V, Pillai S, Ohlendorf D H, Schlievert P M
Abstract excerpt
Streptococcal pyrogenic exotoxins (SPEs) are superantigens that have been implicated in causing streptococcal toxic shock syndrome (STSS). Most notably, SPE serotype A is made by nearly all M-protein serotype 1 and 3 streptococci, the M types most associated with the illness (these strains contain one or more other SPEs, and those proteins are likely also to contribute to disease). We have prepared double-,...
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