Article
Allele-specific quantification of TNFA transcripts in rheumatoid arthritis.
Human genetics - 1 Jun 1996
Brinkman B M, Huizinga T W, Breedveld F C, Verweij C L
Abstract excerpt
Clinical and laboratory studies have suggested a pivotal role for tumor necrosis factor alpha (TNFA) in the pathogenesis of rheumatoid arthritis (RA). Interindividual variation in the expression of TNFA indicates the existence of functionally distinct TNFA alleles that could play a role in susceptibility to TNFA-associated diseases such as RA. In order to determine whether differential TNFA gene expression is...
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