Article
Methodological issues in linkage analyses for psychiatric disorders: secular trends, assortative mating, bilineal pedigrees. Report of the MacArthur Foundation Network I Task Force on Methodological Issues.
Human heredity - 1 Jan 2000
Spence M A, Bishop D T, Boehnke M, Elston R C, Falk C, Hodge S E, Ott J, Rice J, Merikangas K, Kupfer D
Abstract excerpt
A Task Force was assembled to address three data problems in genetic linkage analyses: (1) a secular trend, e.g. cohort effect; (2) positive assortative mating, and (3) bilineal pedigrees. All are cited as reasons for failure to replicate genetic linkage reports. However, we knew of no work demonstrating that these factors could invalidate or bias linkage analyses, nor that they were complications (e.g., variable...
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