Article
Methodological issues in linkage analyses for psychiatric disorders: secular trends, assortative mating, bilineal pedigrees. Report of the MacArthur Foundation Network I Task Force on Methodological Issues.
Human heredity - 1 Jan 2000
Spence M A, Bishop D T, Boehnke M, Elston R C, Falk C, Hodge S E, Ott J, Rice J, Merikangas K, Kupfer D
Abstract excerpt
A Task Force was assembled to address three data problems in genetic linkage analyses: (1) a secular trend, e.g. cohort effect; (2) positive assortative mating, and (3) bilineal pedigrees. All are cited as reasons for failure to replicate genetic linkage reports. However, we knew of no work demon...
Topics
- Cohort Effect
- Confounding Factors, Epidemiologic
- Gene Frequency
- Genes, Dominant
- Genetic Linkage
- Genotype
- Humans
- Marriage
- Mental Disorders
- Mood Disorders
- Pedigree
- Phenotype
- Software