Article
Examination of the phosphoenolpyruvate carboxykinase gene promoter in patients with noninsulin-dependent diabetes mellitus.
The Journal of clinical endocrinology and metabolism - 1 Feb 1996
Ludwig D S, Vidal-Puig A, O'Brien R M, Printz R L, Granner D K, Moller D E, Flier J S
Abstract excerpt
Expression of phosphoenolpyruvate carboxykinase (PEPCK), a rate-limiting enzyme in gluconeogenesis, is under dominant negative regulation by insulin. In this study, we sought to test the hypothesis that mutations in the PEPCK gene promoter may impair the ability of insulin to suppress hepatic glu...
Topics
- Adolescent
- Adult
- Base Sequence
- Diabetes Mellitus, Type 2
- Gluconeogenesis
- Humans
- Insulin
- Insulin Resistance
- Liver
- Molecular Sequence Data
- Mutation
- Phosphoenolpyruvate Carboxykinase (GTP)
- Promoter Regions, Genetic