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Article

Blockage by Adenovirus E4orf6 of Transcriptional Activation by the p53 Tumor Suppressor

7 Jun 1996

Abstract excerpt

The adenovirus E4orf6 protein is shown here to interact with the cellular tumor suppressor protein p53 and to block p53-mediated transcriptional activation. The adenovirus protein inhibited the ability of p53 to bind to human TAFII31, a component of transcription factor IID (TFIID). Earlier work demonstrated that the interaction of p53 with TAFII31 involves a sequence near the NH2-terminus of p53, whereas the...

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PMID: 8633237
DOI: 10.1126/science.272.5267.1470

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