Article
Transcriptional regulation by a point mutant of adenovirus-2 E1a product lacking DNA binding activity.
The Journal of biological chemistry - 5 Oct 1992
Zu Y L, Takamatsu Y, Zhao M J, Maekawa T, Handa H, Ishii S
Abstract excerpt
The adenovirus E1a protein (E1A) regulates transcription through interaction with transcription factors bound to DNA, like cAMP response element BP1/ATF2, or through dissociating E2F transcription factor complex. However, it was also reported that E1A can bind to DNA (Chatterjee, P. K., Bruner, M., Flint, S. J., and Harter, M. L. (1988) EMBO J. 7, 835-841), and it is not clear whether DNA binding of E1A is...
Topics
- Adenovirus E1A Proteins
- Base Sequence
- DNA-Binding Proteins
- Gene Expression Regulation, Viral
- Molecular Sequence Data
- Mutation
- Plasmids
- Promoter Regions, Genetic
- Proto-Oncogene Proteins
- Proto-Oncogenes