Article
Hyperleptinemia and leptin receptor variant Asp600Asn in the obese, hyperinsulinemic KK mouse strain.
Journal of molecular endocrinology - 1 Dec 1998
Igel M, Taylor B A, Phillips S J, Becker W, Herberg L, Joost H G
Abstract excerpt
KK obese mice exhibit a multigenic syndrome of moderate obesity, hyperinsulinemia and hyperglycemia. Here we show that the syndrome is accompanied by a marked elevation of leptin protein in adipose tissue, as well as leptin levels in serum, which corresponds with the degree of obesity. The cDNA s...
Topics
- Adipose Tissue
- Amino Acid Sequence
- Animals
- Base Sequence
- Carrier Proteins
- Crosses, Genetic
- DNA Primers
- DNA, Complementary
- Female
- Genetic Variation
- Insulin
- Leptin
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Mice, Obese
- Microsatellite Repeats