Article
The nu gene acts cell-autonomously and is required for differentiation of thymic epithelial progenitors.
Proceedings of the National Academy of Sciences of the United States of America - 11 Jun 1996
Blackburn C C, Augustine C L, Li R, Harvey R P, Malin M A, Boyd R L, Miller J F, Morahan G
Abstract excerpt
The nude mutation (nu) causes athymia and hairlessness, but the molecular mechanisms by which it acts have not been determined. To address the role of nu in thymogenesis, we investigated whether all or part of the nude thymic epithelium could be rescued by the presence of wild-type cells in nude <--> wild-type chimeric mice. Detailed immunohistochemical analyses revealed that nude-derived cells could persist in...
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