Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis.

doi:10.1128/MCB.16.3.877

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Article

Functional dissection of the human Bcl2 protein: sequence requirements for inhibition of apoptosis.

Molecular and cellular biology - 1 Mar 1996

Hunter J J, Bond B L, Parslow T G

Abstract excerpt

Overexpression of the cytoplasmic oncoprotein Bcl2 blocks programmed cell death (apoptosis) in many cellular systems. To map the sequences in Bcl2 that are necessary for its activity, we created a library of deletion-scanning mutants of this 239-amino-acid protein and tested their abilities to bl...

Topics

Apoptosis
Cell Line
Fibroblasts
Gene Transfer Techniques
Humans
Mutation
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-bcl-2
Sequence Analysis

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