Article
Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene.
The Journal of biological chemistry - 15 Jun 1990
Karsenty G, de Crombrugghe B
Abstract excerpt
Type I collagen, a heterotrimeric protein composed of two alpha 1 chains and one alpha 2 chain, is a major specialized biosynthetic product of fibroblastic cells. We performed a functional dissection of a mouse alpha 1 (I) collagen promoter segment (between -222 and -80) that displays strong activity in vitro and in DNA transfection experiments. Four binding sites for factors present in nuclear extracts of...
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