Article
Two different negative and one positive regulatory factors interact with a short promoter segment of the alpha 1 (I) collagen gene.
The Journal of biological chemistry - 15 Jun 1990
Karsenty G, de Crombrugghe B
Abstract excerpt
Type I collagen, a heterotrimeric protein composed of two alpha 1 chains and one alpha 2 chain, is a major specialized biosynthetic product of fibroblastic cells. We performed a functional dissection of a mouse alpha 1 (I) collagen promoter segment (between -222 and -80) that displays strong acti...
Topics
- Animals
- Base Sequence
- Binding Sites
- Cell Nucleus
- Cells, Cultured
- Collagen
- DNA
- DNA-Binding Proteins
- Deoxyribonuclease I
- Genes
- Kinetics
- Macromolecular Substances
- Methylation
- Mice
- Mice, Inbred Strains
- Molecular Sequence Data
- Mutation
- Nucleotide Mapping