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Article

Inversely correlated expression of p16 and Rb protein in non-small cell lung cancers: an immunohistochemical study.

International journal of cancer - 8 Feb 1996

Sakaguchi M, Fujii Y, Hirabayashi H, Yoon H E, Komoto Y, Oue T, Kusafuka T, Okada A, Matsuda H

Abstract excerpt

Cdk4-mediated phosphorylation of Rb protein is inhibited by p16, a product of a possible tumor suppressor gene. We examined the expression of p16 and Rb protein by means of immunohistochemistry in 61 non-small cell lung cancers and have demonstrated an inverse relationship between the expression of p16 and Rb protein: 28/30 specimens that did not stain for p16 stained for Rb and 21/31 p16-positive specimens did...

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Source

Identifiers

PMID: 8621224
DOI: 10.1002/(SICI)1097-0215(19960208)65:4<442::AID-IJC8>3.0.CO;2-X

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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