Article
Allelic association of gene markers on chromosomes 5q and 11q with atopy and bronchial hyperresponsiveness.
American journal of respiratory and critical care medicine - 1 Apr 1996
Doull I J, Lawrence S, Watson M, Begishvili T, Beasley R W, Lampe F, Holgate T, Morton N E
Abstract excerpt
To investigate genetic factors in asthma and atopy, we sought allelic associations for 12 markers near candidate loci for serum total, immunoglobulin E (IgE), and bronchial hyperresponsiveness (BHR) to inhaled histamine in 131 families comprising 685 individuals, selected randomly without regard to atopy or asthma. Nonparametric linkage and association analyses were performed with the Nonparametric Analysis of...
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