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Article

Analysis of p53 and mdm-2 expression in 18 patients with Sézary syndrome.

British journal of haematology - 1 Mar 1996

Marks D I, Vonderheid E C, Kurz B W, Bigler R D, Sinha K, Morgan D A, Sukman A, Nowell P C, Haines D S

Abstract excerpt

Sézary syndrome is a leukaemic form of cutaneous T-cell lymphoma which presents with multiple cytogenetic abnormalities and responds poorly to chemotherapy. Because of the importance of the p53 tumour suppressor in maintaining genomic stability and in sensitizing transformed cells to DNA damaging agents, we looked for alternations which may affect p53 functions in 18 patients with Sézary syndrome. Cytogenetic...

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Identifiers

PMID: 8616082
DOI: 10.1046/j.1365-2141.1996.439978.x

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