Article
Analysis of p53 and mdm-2 expression in 18 patients with Sézary syndrome.
British journal of haematology - 1 Mar 1996
Marks D I, Vonderheid E C, Kurz B W, Bigler R D, Sinha K, Morgan D A, Sukman A, Nowell P C, Haines D S
Abstract excerpt
Sézary syndrome is a leukaemic form of cutaneous T-cell lymphoma which presents with multiple cytogenetic abnormalities and responds poorly to chemotherapy. Because of the importance of the p53 tumour suppressor in maintaining genomic stability and in sensitizing transformed cells to DNA damaging...
Topics
- Adult
- Aged
- Aged, 80 and over
- Blotting, Northern
- Blotting, Western
- Female
- Genes, p53
- Heterozygote
- Humans
- Immunophenotyping
- Male
- Middle Aged
- Mutation
- Nuclear Proteins
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-mdm2
- Sezary Syndrome
- Survival Analysis