How useful is it clinically to analyse the K-ras mutational status for the diagnosis of exocrine pancreatic cancer? A systematic review and meta-analysis.

doi:10.1111/j.1365-2362.2011.02495.x

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Article

How useful is it clinically to analyse the K-ras mutational status for the diagnosis of exocrine pancreatic cancer? A systematic review and meta-analysis.

European journal of clinical investigation - 1 Jul 2011

Parker Lucy A, Lumbreras Blanca, Lopez Tomás, Hernández-Aguado Ildefonso, Porta Miquel

Abstract excerpt

BACKGROUND: More clinically meaningful diagnostic tests are needed in exocrine pancreatic cancer (EPC). K-ras mutations are the most frequently acquired genetic alteration in EPC. We analysed the diagnostic utility of detecting K-ras mutations through a systematic analysis of the literature. METHODS: We searched PubMed using suitable medical subject headings and text words. Original research articles that...

Topics

Genes, ras
Humans
Mutation
Pancreatic Neoplasms
Research Design
Sensitivity and Specificity

Source

Open in PubMed

Identifiers

PMID: 21391995
DOI: 10.1111/j.1365-2362.2011.02495.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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