Article
Screening for mutations at codon 717 of the amyloid precursor protein gene in Alzheimer's disease.
Psychiatry and clinical neurosciences - 1 Jun 1995
Dai X Y, Hattori M, Hirasawa H, Isse K, Ueki A, Nanko S
Abstract excerpt
Three kinds of missense mutation at codon 717 of amyloid precursor protein (APP) gene (Val --> Ile; Val --> Gly; Val --> Phe) were screened in 114 patients with familial and sporadic Alzheimer's disease (AD), using a rapid testing method for each Val --> Gly and Val --> Phe mutation and Goate's m...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Amyloid beta-Protein Precursor
- Base Sequence
- Codon
- DNA
- Exons
- Female
- Genetic Testing
- Humans
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction