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Article

The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.

Biochemical and biophysical research communications - 15 Aug 1991

Yoshioka K, Miki T, Katsuya T, Ogihara T, Sakaki Y

Abstract excerpt

Alzheimer's disease (AD) is a devastating neurological disorder and the leading cause of dementia among aged individuals. The human amyloid beta protein, which is a cleavage product of amyloid precursor protein (APP), is a major component of the amyloid deposited in the brain of patients with AD. By using PCR direct sequencing of exon 17 (encoding part of the beta protein) of the APP gene, we have found that a...

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Identifiers

PMID: 1908231
DOI: 10.1016/0006-291x(91)91011-z

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The 717Val----Ile substitution in amyloid precursor protein is associated with familial Alzheimer's disease regardless of ethnic groups.PMID 1908231Read ↗

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No founder effect in three novel Alzheimer's disease families with APP 717 Val-->Ile mutation. Clerget-darpoux. French Alzheimer's Disease Study Group.Semantic proximity Read ↗

The Protective A673T Mutation of Amyloid Precursor Protein (APP) in Alzheimer’s DiseaseSemantic proximity Read ↗

A novel silent variant at codon 711 and a variant at codon 708 of the APP sequence detected in Spanish Alzheimer and control cases.Semantic proximity Read ↗

A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of beta-amyloid.Semantic proximity Read ↗

Screening for mutations at codon 717 of the amyloid precursor protein gene in Alzheimer's disease.Semantic proximity Read ↗

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Screening Alzheimer's disease patients for mutations in the amyloid precursor protein gene.Semantic proximity Read ↗

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Early-onset Alzheimer's disease caused by mutations at codon 717 of the beta-amyloid precursor protein gene.Semantic proximity Read ↗

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