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Article

Interactions of CD80 and CD86 with CD28 and CTLA4.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 1996

Ellis J H, Burden M N, Vinogradov D V, Linge C, Crowe J S

Abstract excerpt

CD80 and CD86 are cell surface glycoproteins expressed on a variety of professional APCs. They have attracted much attention due to their function as potent costimulators of T lymphocyte function through their interaction with CD28 and possibly CTLA4. Because inhibitors of this interaction may have therapeutic relevance in human autoimmune disease, we investigated the properties of linear peptides derived from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 8609386

Genes

CTLA4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

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Interactions of CD80 and CD86 with CD28 and CTLA4.PMID 8609386Read ↗

Integration of CD28 and CTLA-4 function results in differential responses of T cells to CD80 and CD86.Semantic proximity Read ↗

Expression of Costimulatory Molecules CD80 and CD86 in Type 2 Immune-Mediated DiseasesSemantic proximity Read ↗

CD28, CTLA‐4 and their ligands: who does what and to whom?Semantic proximity Read ↗

Selective silencing of full-length CD80 but not IgV-CD80 leads to impaired clonal deletion of self-reactive T cells and altered regulation of immune responses.Semantic proximity Read ↗

New polymorphisms of human CD80 and CD86: lack of association with rheumatoid arthritis and systemic lupus erythematosus.Semantic proximity Read ↗

Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses.Semantic proximity Read ↗

Yin–Yang of costimulation: crucial controls of immune tolerance and functionSemantic proximity Read ↗

Structure-Guided Optimization and Functional Characterization of Small Molecule Antagonists Targeting CD28 CostimulationSemantic proximity Read ↗

Interactions between immunogenic peptides and MHC proteins.Semantic proximity Read ↗

Treatment of Murine Lupus with CTLA4IgSemantic proximity Read ↗

Effect of costimulation and the microenvironment on antigen presentation by leukemic cells.Semantic proximity Read ↗

T cell receptor signaling can directly enhance the avidity of CD28 ligand binding.Semantic proximity Read ↗

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