Article
Alpha 2-->3sialyltransferase associated with the synthesis of CA 19-9 in colorectal tumors.
Cancer - 15 Apr 1996
Akamatsu S, Yazawa S, Tachikawa T, Furuta T, Okaichi Y, Nakamura J, Asao T, Nagamachi Y
Abstract excerpt
BACKGROUND: A novel assay method specific for alpha 2-->3sialyltransferase that seems to be responsible for the synthesis of CA 19-9 antigen was developed and the levels of the enzyme in colorectal tumor tissues were measured and compared with the levels of alpha 1-->4fucosyltransferase and the CA 19-9 antigen. METHODS: Lacto-N-biose I (Gal beta 1-->3GlcNAc beta, Lewis(c) [Le(c)]) and 6-O-methyl-Le(c) (Gal beta...
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