Article
Molecular mechanisms of expression of Lewis b antigen and other type I Lewis antigens in human colorectal cancer.
Glycobiology - 1 Jun 1999
Nishihara S, Hiraga T, Ikehara Y, Kudo T, Iwasaki H, Morozumi K, Akamatsu S, Tachikawa T, Narimatsu H
Abstract excerpt
Lewis b (Leb) antigens are gradiently expressed from the proximal to the distal colon, i.e., they are abundantly expressed in the proximal colon, but only faintly in the distal colon. In the distal colon, they begin to increase at the adenoma stage of cancer development and then increase with cancer progression. We aimed to clarify the molecular basis of Leb antigen expression in correlation with the expression...
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