Article
Role of sialosyl Lewis(a) in adhesion of colon cancer cells--the antisense RNA approach.
European journal of biochemistry - 1 Apr 1998
Kłopocki A G, Laskowska A, Antoniewicz-Papis J, Duk M, Lisowska E, Ugorski M
Abstract excerpt
To study whether the adhesion of colon cancer cells to E-selectin can be directly affected by changes in the expression level of sialosyl Le(a) antigen we created a specific loss-of-function phenotype. A stable subclone (CX-1.1) with high expression of sialosyl Le(a) structure, obtained from a heterogenous population of colon carcinoma CX-1 cells, was transfected with an expression vector containing a fragment of...
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