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Detection of the EWS/WT1 Gene Fusion by Reverse Transcriptase-Polymerase Chain Reaction in the Diagnosis of Intra-abdominal Desmoplastic Small Round Cell Tumor

1 Apr 1996

Abstract excerpt

We report two cases of intra-abdominal desmoplastic small round cell tumor with characteristic clinical, histological, immunohistochemical, and ultrastructural features. Fusion of the EWS gene on chromosome 22 and the WT1 gene on chromosome 11, resulting from the chromosomal translocation t(11;22)(p13;q12), was detected by reverse transcriptase polymerase chain reaction (RT-PCR) in both cases. This translocation...

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PMID: 8604806
DOI: 10.1097/00000478-199604000-00002

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