Performance Characteristics of a Reverse Transcriptase–Polymerase Chain Reaction Assay for the Detection of Tumor-specific Fusion Transcripts from Archival Tissue

Abstract excerpt

Pediatric small round cell tumors still pose tremendous diagnostic problems. In difficult cases, the ability to detect tumor-specific gene fusion transcripts for several of these neoplasms, including Ewing sarcoma/peripheral primitive neuroectodermal tumor (ES/PNET), synovial sarcoma (SS), alveolar rhabdomyosarcoma (ARMS), and desmoplastic small round cell tumor (DSRCT) using reverse transcriptase-polymerase...

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