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Genomic and transcriptomic characterization of desmoplastic small round cell tumors.

Genes, chromosomes & cancer - 1 Sept 2021

Sydow Saskia, Versleijen-Jonkers Yvonne M H, Hansson Magnus, van Erp Anke E M, Hillebrandt-Roeffen Melissa H S, van der Graaf Winette T A, Piccinelli Paul, Rissler Pehr, Flucke Uta E, Mertens Fredrik

Abstract excerpt

Desmoplastic small round cell tumor (DSRCT) is a highly aggressive soft tissue tumor primarily affecting children and young adults. Most cases display a pathognomonic EWSR1-WT1 gene fusion, presumably constituting the primary driver event. Little is, however, known about secondary genetic changes that may affect tumor progression. We here studied 25 samples from 19 DSRCT patients using single nucleotide...

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PMID: 33928700
DOI: 10.1002/gcc.22955

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