Article
Detection of mitochondrial genome depletion by a novel cDNA in renal cell carcinoma.
Laboratory investigation; a journal of technical methods and pathology - 1 Mar 1996
Selvanayagam P, Rajaraman S
Abstract excerpt
A cDNA isolated by a subtractive hybridization procedure detected loss of mtDNA and the mRNA coding for NADH dehydrogenase subunit 3 in 8 of 13 tumor kidney tissues obtained from patients with renal cell carcinoma. Sequencing revealed a stretch of nucleotides homologous to the mitochondrial NADH dehydrogenase subunit 3 gene in the middle of the cDNA. The depletion phenomenon was also observed in five of six renal...
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