Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.

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Article

Interaction of p53 with MDM2 is independent of E6 and does not mediate wild type transformation suppressor function.

Oncogene - 1 Sept 1994

Marston N J, Crook T, Vousden K H

Abstract excerpt

Using a new series of p53 mutants targeting the conserved regions we have analysed the relationship of various activities of the protein. Mdm-2 and human papillomavirus (HPV) E6, two proteins which interact with and abrogate p53 function, were shown to bind independently. Deletion of the conserve...

Topics

CDC2 Protein Kinase
Casein Kinases
Cell Transformation, Neoplastic
Mutation
Neoplasm Proteins
Nuclear Proteins
Oncogene Proteins, Viral
Phosphorylation
Protein Kinases
Proto-Oncogene Proteins
Proto-Oncogene Proteins c-mdm2
Repressor Proteins
Transcriptional Activation
Tumor Suppressor Protein p53

Source

Open in PubMed

Identifiers

PMID: 8058335

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8058335-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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