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Article

Modification of C-type inactivating Shaker potassium channels by chloramine-T.

Pflugers Archiv : European journal of physiology - 1 Feb 1996

Schlief T, Schönherr R, Heinemann S H

Abstract excerpt

Shaker potassium channels undergo a slow C-type inactivation which can be hastened dramatically by single-point mutations in or near the pore region. We found that the oxidizing agent chloramine-T (Chl-T) causes an irreversible loss of current for those mutants which show C-type inactivation. For several mutants at position T449, which show a wide spectrum of inactivation time constants, the time constant of...

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Identifiers

PMID: 8596690
DOI: 10.1007/BF02191894

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Modification of C-type inactivating Shaker potassium channels by chloramine-T.PMID 8596690Read ↗

Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels.Semantic proximity Read ↗

Unmasking subtype-dependent susceptibility to C-type inactivation in mammalian Kv1 channels.Semantic proximity Read ↗

Shaker IR T449 mutants separate C- from U-type inactivation.Semantic proximity Read ↗

Closed state-coupled C-type inactivation in BK channels.Semantic proximity Read ↗

ShakerIR and Kv1.5 mutant channels with enhanced slow inactivation also exhibit K⁺ o-dependent resting inactivation.Semantic proximity Read ↗

Role of outer-pore residue Y380 in U-type inactivation of KV2.1 channels.Semantic proximity Read ↗

Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region.Semantic proximity Read ↗

K⁺ channel gating: C-type inactivation is enhanced by calcium or lanthanum outside.Semantic proximity Read ↗

A glimpse into the C-type-inactivated state for a Potassium Channel.Semantic proximity Read ↗

Macroscopic Na+ currents in the "Nonconducting" Shaker potassium channel mutant W434F.Semantic proximity Read ↗

Reciprocal voltage sensor-to-pore coupling leads to potassium channel C-type inactivation.Semantic proximity Read ↗

N-type inactivation and the S4-S5 region of the Shaker K+ channel.Semantic proximity Read ↗

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