Article
Epitope mapping of C1 inhibitor autoantibodies from patients with acquired C1 inhibitor deficiency.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1996
He S, Tsang S, North J, Chohan N, Sim R B, Whaley K
Abstract excerpt
We report six patients with acquired C1 inhibitor (C1-inh) deficiency associated with serum C1-inh autoantibodies and circulating cleaved (96 kDa), functionally inactive C1-inh. In three patients, all of whom had IgG-kappa paraproteins in their sera, the Abs were IgG-kappa. In the remaining three...
Topics
- Aged
- Amino Acid Sequence
- Autoantibodies
- Binding Sites, Antibody
- Complement C1 Inactivator Proteins
- Computer Graphics
- Epitope Mapping
- Female
- Humans
- Immunologic Deficiency Syndromes
- Male
- Middle Aged
- Molecular Sequence Data
- Mutation
- Peptides
- Protein Binding