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Article

Autoantibodies against Complement C1q Specifically Target C1q Bound on Early Apoptotic Cells

31 Jul 2009

Abstract excerpt

Autoantibodies against complement C1q (anti-C1q) are frequently found in patients with systemic lupus erythematosus (SLE). They strongly correlate with the occurrence of severe lupus nephritis, suggesting a pathogenic role in SLE. Because anti-C1q are known to recognize a neoepitope on bound C1q, but not on fluid-phase C1q, the aim of this study was to clarify the origin of anti-C1q by determining the mechanism...

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PMID: 19648280
DOI: 10.4049/jimmunol.0803573

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