Article
Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor.
Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 1990
Dent J A, Berkowitz S D, Ware J, Kasper C K, Ruggeri Z M
Abstract excerpt
Proteolytic cleavage of the von Willebrand factor subunit may be important for processing and/or function of the molecule and is altered in certain subtypes of von Willebrand disease. It results in the generation of two main fragments with apparent molecular masses of 140 kDa and 176 kDa from the...
Topics
- Amino Acid Sequence
- Amino Acids
- Base Sequence
- DNA
- Humans
- Immunoblotting
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction
- von Willebrand Diseases
- von Willebrand Factor