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Article

Heterogeneity of colony stimulating factor-1 gene expression in the skeleton of four osteopetrotic mutations in rats and mice.

Journal of cellular physiology - 1 Feb 1996

Shalhoub V, Jackson M E, Paradise C, Stein G S, Lian J B, Marks S C

Abstract excerpt

Congenital osteopetrosis in mammals is an inherited bone disease caused by aberrations in osteoclast development and/or function. Colony-stimulating factor-1 (CSF-1) promotes formation of osteoclasts and is produced by osteoblasts. Recently, two osteopetrotic mutations (op mouse and tl rat) have...

Topics

Animals
Bone and Bones
Cells, Cultured
Gene Expression
Macrophage Colony-Stimulating Factor
Mice
Mice, Mutant Strains
Mutation
Osteoblasts
Osteopetrosis
RNA, Messenger
Rats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Rats, Mutant Strains

Reference Values

Skull

Transforming Growth Factor beta

Source

Identifiers

PMID: 8591994
DOI: 10.1002/(SICI)1097-4652(199602)166:2<340::AID-JCP12>3.0.CO;2-F

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8591994-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Heterogeneity of colony stimulating factor-1 gene expression in the skeleton of four osteopetrotic mutations in rats and mice.PMID 8591994Read ↗

The osteopetrotic mutation toothless ( tl ) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossificationSemantic proximity Read ↗

Gene expression during skeletal development in three osteopetrotic rat mutations. Evidence for osteoblast abnormalities.Semantic proximity Read ↗

Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat.Semantic proximity Read ↗

Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?Semantic proximity Read ↗

Abnormalities of phosphoprotein gene expression in three osteopetrotic rat mutations: elevated mRNA transcripts, protein synthesis, and accumulation in bone of mutant animals.Semantic proximity Read ↗

Colony stimulating factor 1 (CSF-1) and its in vivo role as delineated using osteopetrotic op/op mice.Semantic proximity Read ↗

Rescue of the colony-stimulating factor 1 (CSF-1)-nullizygous mouse (Csf1(op)/Csf1(op)) phenotype with a CSF-1 transgene and identification of sites of local CSF-1 synthesis.Semantic proximity Read ↗

The effects of colony-stimulating factor-1 (CSF-1) on the development of osteoclasts and their expression of tartrate-resistant acid phosphatase (TRAP) in toothless (tl-osteopetrotic) rats.Semantic proximity Read ↗

The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development.Semantic proximity Read ↗

The biology and action of colony stimulating factor-1.Semantic proximity Read ↗

Lessons from osteopetrotic mutations in animals: impact on our current understanding of osteoclast biology.Semantic proximity Read ↗

Colony-stimulating factor 1 when combined with parathyroid hormone or 1,25-dihydroxyvitamin D can produce osteoclasts in cultured neonatal metatarsals from toothless (tl-osteopetrotic) rats.Semantic proximity Read ↗

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