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Article

Heterogeneity of colony stimulating factor-1 gene expression in the skeleton of four osteopetrotic mutations in rats and mice.

Journal of cellular physiology - 1 Feb 1996

Shalhoub V, Jackson M E, Paradise C, Stein G S, Lian J B, Marks S C

Abstract excerpt

Congenital osteopetrosis in mammals is an inherited bone disease caused by aberrations in osteoclast development and/or function. Colony-stimulating factor-1 (CSF-1) promotes formation of osteoclasts and is produced by osteoblasts. Recently, two osteopetrotic mutations (op mouse and tl rat) have been shown to have reductions in CSF-1 activity, and CSF-1 injections improve the skeletal manifestations in each....

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Identifiers

PMID: 8591994
DOI: 10.1002/(SICI)1097-4652(199602)166:2<340::AID-JCP12>3.0.CO;2-F

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Heterogeneity of colony stimulating factor-1 gene expression in the skeleton of four osteopetrotic mutations in rats and mice.PMID 8591994Read ↗

The osteopetrotic mutation toothless ( tl ) is a loss-of-function frameshift mutation in the rat Csf1 gene: Evidence of a crucial role for CSF-1 in osteoclastogenesis and endochondral ossificationSemantic proximity Read ↗

Gene expression during skeletal development in three osteopetrotic rat mutations. Evidence for osteoblast abnormalities.Semantic proximity Read ↗

Mutation of macrophage colony stimulating factor (Csf1) causes osteopetrosis in the tl rat.Semantic proximity Read ↗

Is the osteopetrotic (op/op mutant) mouse completely deficient in expression of macrophage colony-stimulating factor?Semantic proximity Read ↗

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Colony stimulating factor 1 (CSF-1) and its in vivo role as delineated using osteopetrotic op/op mice.Semantic proximity Read ↗

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The effects of colony-stimulating factor-1 (CSF-1) on the development of osteoclasts and their expression of tartrate-resistant acid phosphatase (TRAP) in toothless (tl-osteopetrotic) rats.Semantic proximity Read ↗

The heterogeneity of the osteopetroses reflects the diversity of cellular influences during skeletal development.Semantic proximity Read ↗

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Lessons from osteopetrotic mutations in animals: impact on our current understanding of osteoclast biology.Semantic proximity Read ↗

Colony-stimulating factor 1 when combined with parathyroid hormone or 1,25-dihydroxyvitamin D can produce osteoclasts in cultured neonatal metatarsals from toothless (tl-osteopetrotic) rats.Semantic proximity Read ↗

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